Oral Contraceptives: Increase in glucuronidation causing elevated plasma clearance in addition to a decreased fifty percent-lifetime of acetaminophen.
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Lamotrigine: Serum lamotrigine concentrations could be decreased, developing a minimize in therapeutic results.
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Insufficient information exists to generate appropriate dosing tips concerning the use of possibly propoxyphene by yourself or in combination with acetaminophen in patients with hepatic or renal impairment for a functionality of degree of impairment. Greater more info plasma concentrations and/or delayed elimination could arise in case of impaired hepatic operate and/or impaired renal perform (see CLINICAL PHARMACOLOGY).
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